Shutter Vector, Resistance Genes and Candida Albicans Transformant Library for Identification and Cloning of Resistance and Virulence Genes
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- Categories
- Biotechnology
- Summary
- Currently, C. albicans genes are analyzed by disrupting both copies, one at a time. This approach is laborious and may not reveal a particular phenotype if the gene is redundant. Additionally, deletions of many genes can be lethal.
This WSU technology involves a functional genomics approach to C. albicans research, by studying the effect of overexpression of a single gene on phenotype. The process introduces normal genes back into C. albicans at a high copy number, so that the gene is overexpressed and changes the phenotype of the recipient cell. Biological materials available through this technology platform include the shuttle vectors themselves; the transformants; genes in vectors
libraries; and individual plasmids with tailored genes. Biological materials licensing is available.
- File number
- 04-687
- Contact
- Anne DiSante
Director, Technology Transfer Office
Phone: 313-577-5541
Fax : 313-577-2814
anne.disante@wayne.edu