Nanoparticle Drug Delivery Compounds for Hydrophilic Drugs
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- Categories
- Bioengineering, Pharmaceuticals
- Summary
- WSU researchers have developed a nanoparticle formulation for the encapsulation of hydrophilic drugs with high efficiency. Encapsulation efficiency close to 100% has been achieved. Further, these nanoparticles demonstrate sustained release of hydrophilic drugs over a period of weeks (~60-80% of encapsulated drug released over a period of 4 weeks). As a comparison, published studies that investigate the use of other state of the art nanoparticles with water-soluble drugs report sustained release only over a period of few hours. Additionally, due to high surface area afforded by nanoparticles, the efficiency of encapsulation of water-soluble drugs to date has been very poor (<50%).
The WSU technology is differentiated by the observed ability to encapsulate hydrophilic drugs in nanoparticles with high efficiency and to sustain the release of hydrophilic drugs from the nanoparticles over a period of weeks to months.
- File number
- 05-750
- Publications
- A provisional patent application is on file.
- Contact
- Anne DiSante
Director, Technology Transfer Office
Phone: 313-577-5541
Fax : 313-577-2814
anne.disante@wayne.edu