Chicken Interleukin-2 for use as Vaccine Adjuvant
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- Categories
- Biotechnology, Pharmaceuticals
- Summary
- WSU researchers have cloned and patented chicken IL-2 and related avian lymphokines for use as avian vaccine adjuvants. The inventors have shown experimentally that chicken IL-2 can enhance vaccine effectiveness in chickens. Future research to further enable this technology will likely include optimization of delivery methods. IL-2 has a short serum half-life, and for maximum efficacy must be attached to, or closely associated with, the vaccine antigen(s). Various studies have utilized chicken IL-2 fused to antigen, expressed by viral vaccine vectors and expressed in DNA vaccines. In general, the addition of IL-2 has enhanced both the magnitude and the quality of immune responses.
- File number
- 95-344
- Publications
- A significant patent portfolio with foreign rights is available.
- Contact
- Anne DiSante
Director, Technology Transfer Office
Phone: 313-577-5541
Fax : 313-577-2814
anne.disante@wayne.edu