Method to Stabilize Suspension-Based Formulations in Hydrofluoroalkane Propellants with Nanoparticles
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- Categories
- Bioengineering, Pharmaceuticals
- Summary
- This invention is a new method for engineering porous drug particles with enhanced physical stability and aerosol characteristics in hydrofluoroalkane (HFA) propellants for use in pressure metered-dose inhaler (pMDI) formulations. The approach consists of preparing drug particles containing excipients, which are later remove, resulting in the generation of a porous drug structure. The HFC propellant is capable of penetrating into porous drug particles, thus enhancing the physical stability of the otherwise unstable formulation. This stabilization effect is a significant improvement over existing commercial formulations. Furthermore, this invention enables a wide variety of drugs to be formulated free of environmentally toxic chlorofluorocarbons (CFCs).
- File number
- 07-853
- Publications
- We are seeking industrial partners to further develop/license this invention. A provisional patent application is on file.
- Contact
- Anne DiSante
Director, Technology Transfer Office
Phone: 313-577-5541
Fax : 313-577-2814
anne.disante@wayne.edu