Method for engineering polar drug particles with surface-trapped hydrofluoroalkane-philes
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- Categories
- Bioengineering, Pharmaceuticals
- Summary
- The invention disclosed is a novel method for preparation of spheroidal/spherical polar drug particles with surface-trapped hydrofluoroalkane-philes. This approach can impart long-term physical stability to drug particles dispersed in hydrofluoroalkane (HFA) for use in pressure metered-dose inhalers (pMDI).
This advanced technology has advantages compared to what is currently the industry standard, where co-solvents have to be used alongside surfactants to attain similar (or inferior) stability of the dispersion-based formulation. The method is also superior in that no free stabilizers remain in solution thereby reducing toxicity. This invention is expected to be applicable to small molecules and biomolecules that can be formulated free of environmentally toxic chlorofluorocarbons (CFCs).
- File number
- 07-851
- Publications
- We are seeking industrial partners to further develop/license this invention. A provisional patent application is on file.
- Contact
- Anne DiSante
Director, Technology Transfer Office
Phone: 313-577-5541
Fax : 313-577-2814
anne.disante@wayne.edu